Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
نویسندگان
چکیده
منابع مشابه
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.
There have been many conflicting reports concerning the association of the DRD2 locus with alcohol dependence (AD). To investigate whether these findings could be reconciled by considering the genomic region of DRD2 in greater detail, we conducted two separate association studies of AD in 1220 European-American subjects using family-based (488 subjects) and case-control (318 cases and 414 contr...
متن کاملANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.
CONTEXT The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging. OBJECTIVE To examine association of 1430 candidate gene single-nucleotide polymorphisms (SNPs) with heroin dependence, reporting here only the 71 SNPs in the chromosome 11 gene cluster (NCAM1, TTC12, ANKK1, DRD2) that include the strongest ob...
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Genetic studies have long suggested the important role of the DRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes the NCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approa...
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Jolanta Kucharska-Mazur1, Anna Grzywacz1, Justyna PełkaWysiecka1, Agnieszka samochowiec1,2, Hans Rommelspacher3, Jerzy samochowiec1: 1 Department of Psychiatry, Pomeranian Medical University, 26 Broniewskiego Str., 71-460 Szczecin, Poland. 2 Department of Clinical Psychology and Psychoprophylaxis, Institute of Psychology, University of Szczecin, 69 Krakowska Str., 71-004 Szczecin, Poland. 3 Dep...
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این مطالعه به نقد و بررسی مفهوم اسطوره ی رویای امریکایی در سه نمایشنامه ی قرن بیستم امریکایی می پردازد، که این نمایشنامه ها عبارتند از: the iceman cometh (مرد یخین می آید) نوشته ی یوجین اونیل، 1940؛ desirea streetcar named (اتوبوسی به نام هوس) نوشته ی تنسی ویلیامز، 1947؛ و in the sun raisin a (انگور خشکیده در آفتاب) ، نوشته ی لورین هنزبری، 1958. هدف از این بررسی، ابتدا شناخت مفهوم رویای امری...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2006
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddl426